PEGylation of lipophilic SN38 prodrug with DSPE-mPEG2000 versus cremophor EL: comparative study for intravenous chemotherapy
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چکیده
منابع مشابه
Influence of formulation vehicle on metronomic taxane chemotherapy: albumin-bound versus cremophor EL-based paclitaxel.
PURPOSE Low-dose metronomic chemotherapy treatments, especially when combined with 'dedicated' antiangiogenic agents, can induce significant antitumor activity without serious toxicity in various preclinical models. It remains unclear, however, whether some cytotoxic drugs are better suited for metronomic regimens than others. Paclitaxel appears to be a strong candidate for metronomic chemother...
متن کاملHyperthermic intraperitoneal chemotherapy plus high-frequency diathermic therapy followed by intravenous chemotherapy versus intravenous chemotherapy alone for postoperative adjuvant treatment of gastrointestinal cancer: a comparative research study.
PURPOSE To evaluate the therapeutic efficacy and toxicity of hyperthermic intraperitoneal chemotherapy (HIPEC) plus high-frequency diathermic therapy (HFDT) followed by intravenous chemotherapy vs intravenous chemotherapy alone for adjuvant treatment of postoperative gastrointestinal neoplasms. METHODS Fifty-two gastrointestinal carcinoma patients who were radically operated were enrolled and...
متن کاملPhase I trial of cremophor EL with bolus doxorubicin.
Cremophor EL (cremophor), a component of the paclitaxel formulation, can potentially reverse P-glycoprotein-associated multidrug resistance. A Phase I trial of cremophor as a 6-h infusion every 3 weeks was performed with bolus doxorubicin (50 mg/m2). The cremophor dose was escalated from 1 to 60 ml/m2. A standard paclitaxel premedication was given before cremophor. Using a bioassay, potentially...
متن کاملSuspected anaphylactic reaction to Cremophor EL.
There have been several reports of anaphylactoid reactions to the intravenous anaesthetic drugs Althesin (alphaxalone and alphadolone) and propanidid (Epontol).' The culprit in some of these reactions may have been Cremophor EL, a surfactant common to both drug formulations. Cremophor EL is produced by the epoxylation of castor oil and is actually a complex mixture of compounds. We report a cas...
متن کاملInfluence of Cremophor El on the bioavailability of intraperitoneal paclitaxel.
It has been hypothesized that the paclitaxel vehicle Cremophor EL (CrEL) is responsible for nonlinear drug disposition by micellar entrapment. To gain further insight into the role of CrEL in taxane pharmacology, we studied the pharmacokinetics of paclitaxel in the presence and absence of CrEL after i.p. and i.v. dosing. Patients received an i.p. tracer dose of [G-(3)H]paclitaxel in ethanol wit...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2019
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717544.2019.1587045